What we do
Understanding and engineering the basic principles of life
Our mission is to advance the understanding of the physics of living systems across scales to bring solutions to some of the world’s most pressing bioengineering and health issues. To achieve this, we combine novel physics-centered experimental methods, system-level computational approaches, and conceptual bottom-up theory to decipher the physical laws governing the dynamic organization of life from molecules to cells. We re-engineer life-like processes and systems by employing state-of-the-art technologies and by developing novel life-inspired approaches. Our initiative is jointly supported by the LMU Center for NanoScience, the LMU Gene Center, and the LMU Arnold Sommerfeld Center for Theoretical Physics.
Engineering Life Seminar
January 26 at 5.00 pm CET
LMU Faculty of Physics, Kleiner Physikhörsaal N020
Hagan Bayley, Professor of Chemical Biology, University of Oxford
Two aspects of protein nanopore technology that require more thought
By recording the ionic current driven through single engineered protein nanopores under a transmembrane potential, individual bond-making and bond-breaking steps can be monitored with sub-millisecond time-resolution. By using this approach, mobile molecules, walkers and hoppers, can be observed in real time. The chemistry might be applied to the stepwise translocation of biopolymers for sequencing applications. However, the approaches taken require more thought. Do we fully understand the stepping mechanisms? How can we propel polymers over greater distances? In a second endeavour, there has been a flurry of activity around “protein sequencing” with nanopore technology. This area also needs careful consideration. What must be accomplished to obtain significant biological information? What are the mechanisms that underlie the approaches that are being considered?
Upcoming seminars
February 9
Maartje Bastings, EPFL
Rigidity at the Nanoscale: Engineering (Super-)Selective Interactions with DNA
February 16
Michael Levin, Tufts University
Engineering with agential materials: from evolution to biological robotics
Past seminars
Alexander A. Green
Biomedical Engineering Department, Boston University
Building Biological Control Systems Through RNA Engineering
Jan-Philipp Junker
Max Delbrück Center for Molecular Medicine
Cell fate decisions in health and disease
Ebbe Sloth Andersen
Aarhus University
RNA origami: The art of folding an RNA strand to create nanoscale shapes
Hao Yan
Arizona State University
Designer Nucleic Acid Architectures for Programmable Self-assembly
Joachim Spatz
MPI for Medical Research Heidelberg
Matter to Life: Bottom-Up Assembly of Synthetic Cells
Stirling Churchman
Harvard Medical School
The dynamics of gene expression, from the nucleus to mitochondria
Donald E. Ingber
Wyss Institute for Biologically Inspired Engineering at Harvard University
Human Organ Chips: Reverse Engineering Human Biology for Medical Applications
Jochen Guck
MPI for the Science of Light
Erlangen
Physical states of cells somewhere between life and death
Alena Khmelinskaia
University of Bonn
Expanding the repertoire of de novo protein assemblies
Steffen Rulands
MPI for the Physics of Complex Systems
Understanding collective processes in the cell nucleus using single-cell genomics
Cameron Myhrvold
Princeton University
CRISPR-based technologies for detecting and destroying RNA viruses
Cathleen Zeymer
TU München
Design and engineering of lanthanide-binding proteins: from de novo metal coordination to catalysis
Irene Chen
University of California at Los Angeles
Emergent by-products of RNA evolution
Stephan W. Grill
MPI of Molecular Cell Biology and Genetics
Condensation of proteins on and with DNA
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